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+--- Thread: HLA-DRB1 gene explained (/Thread-HLA-DRB1-gene-explained)
HLA-DRB1 gene explained - KeithD - 11-02-2023
The HLA-DRB1 gene is part of the human leukocyte antigen (HLA) complex, which plays a critical role in the immune system's ability to recognize and respond to foreign invaders, such as bacteria and viruses. The HLA-DRB1 gene is located on chromosome 6 and encodes for a protein that is found on the surface of immune cells and helps to present antigens to the immune system.
The HLA-DRB1 gene is strongly associated with rheumatoid arthritis (RA), with certain variants of the gene increasing a person's risk of developing the disease. The specific variants of the HLA-DRB1 gene that have been linked to RA are called shared epitope alleles, and they are present in over 70% of people with the disease.
It is important to note that the HLA-DRB1 gene is only one of many factors that contribute to the development of RA. A combination of genetic, environmental, and lifestyle factors likely play a role in the onset and progression of the disease. The presence of the HLA-DRB1 gene may increase a person's risk of developing RA, but it is not a guarantee that they will develop the disease.